Some of the most typical brings about of blindness involve the degeneration of photoreceptors meantime within the neural retina; photoreceptor substitute treatment might restore some vision in these individuals. Embryonic stem cells (ESCs) could, in principle, present a source of photoreceptors to restore the retina. We've got previously shown that retinal progenitors may be efficiently derived from human ESCs. We now demonstrate that retinal cells derived from human ESCs will migrate into mouse retinas following intraocular injection, HSP90 settle in to the ideal layers, and express markers for differentiated cells, which includes the two rod and cone photoreceptor cells. Following transplantation with the cells to the subretinal room of adult Crx(-/-) mice (a model of Leber's Congenital Amaurosis), the hESC-derived retinal cells differentiate into practical photoreceptors and restore light responses towards the animals. These results demonstrate that hESCs can, in principle, be employed for photoreceptor replacement therapies.